Solvolysis of the tumor-inhibiting ru(III)-complex trans-tetrachlorobis(indazole)ruthenate(III)

Thomas Pieper; Wolfgang Peti; Bernhard Keppler

doi:10.1155/MBD.2000.225

Solvolysis of the tumor-inhibiting ru(III)-complex trans-tetrachlorobis(indazole)ruthenate(III)

Thomas Pieper
, Wolfgang Peti
, Bernhard Keppler

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

The ruthenium(III) complex Hlnd trans-[RuCl4(ind)2], with two trans-standing indazole (ind) ligands bound to ruthenium via nitrogen, shows remarkable activity in different tumor models in vitro and in vivo. The solvolysis of the complex trans-[RuCl4(ind)2] has been investigated by means of spectroscopic techniques (UV/vis, NMR) in different solvents. We investigated the indazolium as well as the sodium salt, the latter showing improved solubility in water. In aqueous acetonitrile and ethanol the solvolysis results in one main solvento complex. The hydrolysis of the complex is more complicated and depends on the pH of the solution as well as on the buffer system.

Original language	English
Pages (from-to)	225-232
Number of pages	8
Journal	Metal-Based Drugs : MBD
Volume	7
Issue number	4
DOIs	https://doi.org/10.1155/MBD.2000.225
Publication status	Published - 2000

Austrian Fields of Science 2012

1040 Chemistry

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10.1155/MBD.2000.225

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title = "Solvolysis of the tumor-inhibiting ru(III)-complex trans-tetrachlorobis(indazole)ruthenate(III)",

abstract = "The ruthenium(III) complex Hlnd trans-[RuCl4(ind)2], with two trans-standing indazole (ind) ligands bound to ruthenium via nitrogen, shows remarkable activity in different tumor models in vitro and in vivo. The solvolysis of the complex trans-[RuCl4(ind)2] has been investigated by means of spectroscopic techniques (UV/vis, NMR) in different solvents. We investigated the indazolium as well as the sodium salt, the latter showing improved solubility in water. In aqueous acetonitrile and ethanol the solvolysis results in one main solvento complex. The hydrolysis of the complex is more complicated and depends on the pH of the solution as well as on the buffer system.",

author = "Thomas Pieper and Wolfgang Peti and Bernhard Keppler",

note = "Zeitschrift: Metal-Based Drugs Coden: MBADE Affiliations: Institute of Inorganic Chemistry, University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria Adressen: Keppler, B.K.; Institute of Inorganic Chemistry; University of Vienna; Waehringerstr. 42 A-1090 Vienna, Austria Source-File: ChemieErgScopus.csv Import aus Scopus: 2-s2.0-0034529905 Importdatum: 09.01.2007 14:14:46 12.02.2008: Datenanforderung 2112 (Import Sachbearbeiter) 09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)",

year = "2000",

doi = "10.1155/MBD.2000.225",

language = "English",

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journal = "Metal-Based Drugs : MBD",

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AU - Pieper, Thomas

AU - Peti, Wolfgang

AU - Keppler, Bernhard

N1 - Zeitschrift: Metal-Based Drugs Coden: MBADE Affiliations: Institute of Inorganic Chemistry, University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria Adressen: Keppler, B.K.; Institute of Inorganic Chemistry; University of Vienna; Waehringerstr. 42 A-1090 Vienna, Austria Source-File: ChemieErgScopus.csv Import aus Scopus: 2-s2.0-0034529905 Importdatum: 09.01.2007 14:14:46 12.02.2008: Datenanforderung 2112 (Import Sachbearbeiter) 09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)

PY - 2000

Y1 - 2000

N2 - The ruthenium(III) complex Hlnd trans-[RuCl4(ind)2], with two trans-standing indazole (ind) ligands bound to ruthenium via nitrogen, shows remarkable activity in different tumor models in vitro and in vivo. The solvolysis of the complex trans-[RuCl4(ind)2] has been investigated by means of spectroscopic techniques (UV/vis, NMR) in different solvents. We investigated the indazolium as well as the sodium salt, the latter showing improved solubility in water. In aqueous acetonitrile and ethanol the solvolysis results in one main solvento complex. The hydrolysis of the complex is more complicated and depends on the pH of the solution as well as on the buffer system.

AB - The ruthenium(III) complex Hlnd trans-[RuCl4(ind)2], with two trans-standing indazole (ind) ligands bound to ruthenium via nitrogen, shows remarkable activity in different tumor models in vitro and in vivo. The solvolysis of the complex trans-[RuCl4(ind)2] has been investigated by means of spectroscopic techniques (UV/vis, NMR) in different solvents. We investigated the indazolium as well as the sodium salt, the latter showing improved solubility in water. In aqueous acetonitrile and ethanol the solvolysis results in one main solvento complex. The hydrolysis of the complex is more complicated and depends on the pH of the solution as well as on the buffer system.

U2 - 10.1155/MBD.2000.225

DO - 10.1155/MBD.2000.225

M3 - Article

SN - 0793-0291

VL - 7

SP - 225

EP - 232

JO - Metal-Based Drugs : MBD

JF - Metal-Based Drugs : MBD

IS - 4

ER -

Solvolysis of the tumor-inhibiting ru(III)-complex trans-tetrachlorobis(indazole)ruthenate(III)

Abstract

Austrian Fields of Science 2012

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