Abstract
The commercially available and experimentally convenient (bp 65 °C) difluoromethyltrimethylsilane (TMSCHF 2) is proposed as a valuable difluoromethylating transfer reagent for delivering the CHF 2 moiety to various heteroatom-based electrophiles. Upon activation with an alkoxide, a conceptually intuitive nucleophilic displacement directly furnishes in high yields the bench-stable analogues.
Original language | English |
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Pages (from-to) | 5761-5764 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 58 |
Issue number | 38 |
DOIs | |
Publication status | Published - 2022 |
Austrian Fields of Science 2012
- 104015 Organic chemistry
Keywords
- Indicators and Reagents