Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

Philipp Fronik; Isabella Poetsch; Alexander Kastner; Theresa Mendrina; Sonja Hager; Katharina Hohenwallner; Hemma Schueffl; Dietmar Herndler-Brandstetter; Gunda Koellensperger; Evelyn Rampler; Joanna Kopecka; Chiara Riganti; Walter Berger; Bernhard K. Keppler; Petra Heffeter; Christian R. Kowol

doi:10.1021/acs.jmedchem.1c00770

Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

Philipp Fronik, Isabella Poetsch, Alexander Kastner, Theresa Mendrina, Sonja Hager, Katharina Hohenwallner, Hemma Schueffl, Dietmar Herndler-Brandstetter, Gunda Koellensperger, Evelyn Rampler, Joanna Kopecka, Chiara Riganti, Walter Berger, Bernhard K. Keppler, Petra Heffeter (Corresponding author), Christian R. Kowol (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	12132-12151
Number of pages	20
Journal	Journal of Medicinal Chemistry
Volume	64
Issue number	16
DOIs	https://doi.org/10.1021/acs.jmedchem.1c00770
Publication status	Published - 26 Aug 2021

Austrian Fields of Science 2012

104003 Inorganic chemistry
301207 Pharmaceutical chemistry
301305 Medical chemistry

Keywords

INDOLEAMINE 2,3-DIOXYGENASE
ANTICANCER ACTIVITY
DENDRITIC CELLS
HUMAN CANCER
COMPLEXES
INHIBITION
OXALIPLATIN
RESISTANCE
REDUCTION
HALLMARKS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.jmedchem.1c00770

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Fronik, P., Poetsch, I., Kastner, A., Mendrina, T., Hager, S., Hohenwallner, K., Schueffl, H., Herndler-Brandstetter, D., Koellensperger, G., Rampler, E., Kopecka, J., Riganti, C., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2021). Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands. Journal of Medicinal Chemistry, 64(16), 12132-12151. https://doi.org/10.1021/acs.jmedchem.1c00770

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title = "Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands",

keywords = "INDOLEAMINE 2,3-DIOXYGENASE, ANTICANCER ACTIVITY, DENDRITIC CELLS, HUMAN CANCER, COMPLEXES, INHIBITION, OXALIPLATIN, RESISTANCE, REDUCTION, HALLMARKS",

author = "Philipp Fronik and Isabella Poetsch and Alexander Kastner and Theresa Mendrina and Sonja Hager and Katharina Hohenwallner and Hemma Schueffl and Dietmar Herndler-Brandstetter and Gunda Koellensperger and Evelyn Rampler and Joanna Kopecka and Chiara Riganti and Walter Berger and Keppler, {Bernhard K.} and Petra Heffeter and Kowol, {Christian R.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Published by American Chemical Society.",

year = "2021",

month = aug,

day = "26",

doi = "10.1021/acs.jmedchem.1c00770",

language = "English",

volume = "64",

pages = "12132--12151",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "AMER CHEMICAL SOC",

number = "16",

}

Fronik, P, Poetsch, I, Kastner, A, Mendrina, T, Hager, S, Hohenwallner, K, Schueffl, H, Herndler-Brandstetter, D, Koellensperger, G , Rampler, E, Kopecka, J, Riganti, C, Berger, W, Keppler, BK, Heffeter, P & Kowol, CR 2021, 'Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands', Journal of Medicinal Chemistry, vol. 64, no. 16, pp. 12132-12151. https://doi.org/10.1021/acs.jmedchem.1c00770

TY - JOUR

T1 - Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

AU - Fronik, Philipp

AU - Poetsch, Isabella

AU - Kastner, Alexander

AU - Mendrina, Theresa

AU - Hager, Sonja

AU - Hohenwallner, Katharina

AU - Schueffl, Hemma

AU - Herndler-Brandstetter, Dietmar

AU - Koellensperger, Gunda

AU - Rampler, Evelyn

AU - Kopecka, Joanna

AU - Riganti, Chiara

AU - Berger, Walter

AU - Keppler, Bernhard K.

AU - Heffeter, Petra

AU - Kowol, Christian R.

PY - 2021/8/26

Y1 - 2021/8/26

KW - INDOLEAMINE 2,3-DIOXYGENASE

KW - ANTICANCER ACTIVITY

KW - DENDRITIC CELLS

KW - HUMAN CANCER

KW - COMPLEXES

KW - INHIBITION

KW - OXALIPLATIN

KW - RESISTANCE

KW - REDUCTION

KW - HALLMARKS

UR - http://www.scopus.com/inward/record.url?scp=85114176801&partnerID=8YFLogxK

U2 - 10.1021/acs.jmedchem.1c00770

DO - 10.1021/acs.jmedchem.1c00770

M3 - Article

SN - 0022-2623

VL - 64

SP - 12132

EP - 12151

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 16

ER -

Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

Austrian Fields of Science 2012

Keywords

UN SDGs

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