Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities

Thomas Erker; Maria Galanski; Christian Studenik

doi:10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L

Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities

Thomas Erker, Maria Galanski, Christian Studenik

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

Original language	English
Pages (from-to)	58-62
Number of pages	5
Journal	Archiv der Pharmazie
Volume	333
Issue number	2-3
DOIs	https://doi.org/10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L
Publication status	Published - 2000

Austrian Fields of Science 2012

3012 Pharmacy, Pharmacology, Toxicology

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10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L

Cite this

@article{60fc64cece1f48f797a4419d501a5374,

title = "Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities",

abstract = "In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.",

author = "Thomas Erker and Maria Galanski and Christian Studenik",

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year = "2000",

doi = "10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L",

language = "English",

volume = "333",

pages = "58--62",

journal = "Archiv der Pharmazie",

issn = "0365-6233",

number = "2-3",

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T1 - Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities

AU - Erker, Thomas

AU - Galanski, Maria

AU - Studenik, Christian

N1 - DOI: 10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L Coden: ARPMA Affiliations: Inst. of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria; Inst. of Pharmacology and Toxicology, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria Source-File: MedPharmChemScopus_iso.csv Import aus Scopus: 2-s2.0-0034117203 Importdatum: 22.11.2006 17:14:51 09.08.2007: Datenanforderung 1812 (Import Sachbearbeiter) 09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)

PY - 2000

Y1 - 2000

N2 - In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

AB - In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

U2 - 10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L

DO - 10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L

M3 - Article

VL - 333

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EP - 62

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

SN - 0365-6233

IS - 2-3

ER -