Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages

Sheyda Bahiraii, Martin Brenner, Fangfang Yan, Wolfram Weckwerth, Elke H Heiss

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Article number935692
Number of pages14
JournalFrontiers in Immunology
Volume13
DOIs
Publication statusPublished - 2 Aug 2022

Austrian Fields of Science 2012

  • 301209 Pharmacy

Keywords

  • Animals
  • Interleukin-1beta/metabolism
  • Isothiocyanates/pharmacology
  • Lipopolysaccharides
  • Macrophages/drug effects
  • Mice
  • Pyruvate Kinase/metabolism
  • Sulfoxides/pharmacology
  • sulforaphane
  • PKM2
  • glycolysis
  • M1 polarization
  • interleukin 1 beta
  • macrophages
  • TARGET
  • METABOLITES
  • DETERMINANT
  • CANCER
  • GLYCOLYSIS
  • NRF2
  • INFLAMMATION
  • DYSFUNCTION
  • PROTEINS
  • MODULATION

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