Abstract
The new compound thienodiltiazem was synthesized and investigated regarding structure-activity relations and calcium antagonistic properties. Isometric contraction force was measured in guinea-pig papillary muscles and chronotropic activity was studied in right atria of guinea pigs. Compared to the parent drug diltiazem (CAS 42399-41-7) the thieno derivative had a more potent negative chronotropic effect on spontaneously beating right atria and a more potent inotropic effect on papillary muscles. The negative inotropic action was reversed by increasing the extracellular calcium concentration.
| Original language | English |
|---|---|
| Pages (from-to) | 757-761 |
| Number of pages | 5 |
| Journal | Arzneimittel-Forschung |
| Issue number | 12 |
| Publication status | Published - 2007 |
Austrian Fields of Science 2012
- 301206 Pharmacology
- 301207 Pharmaceutical chemistry