Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate

Martin Meyer; Christian Dohmen; Alexander Philipp; Daniel Kiener; Gelja Maiwald; Christina Scheu; Manfred Ogris; Ernst Wagner

doi:10.1021/mp9000124

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate

Martin Meyer
, Christian Dohmen
, Alexander Philipp
, Daniel Kiener
, Gelja Maiwald
, Christina Scheu
, Manfred Ogris
, Ernst Wagner

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	752-762
Number of pages	11
Journal	Molecular Pharmaceutics
Volume	6
Issue number	3
DOIs	https://doi.org/10.1021/mp9000124
Publication status	Published - 2009
Externally published	Yes

Funding

This work was funded by the DFG SFB486, OG 63/4-1, Excellence Cluster "Nanosystems Initiative Munich (NIM)" and EC project GIANT. We are very grateful to Olga Bruck for assistance in preparing the manuscript.

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

Nucleic acid delivery
siRNA conjugate
bioresponsive
endosomolytic peptide
melittin
IN-VIVO DELIVERY
GENE DELIVERY
RNA INTERFERENCE
PLASMID DNA
TUMOR
ACID
PEPTIDES
VECTORS
NANOPARTICLES
THERAPEUTICS

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10.1021/mp9000124

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@article{81479865b18f45cf8a7b6fe7be764555,

title = "Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate",

keywords = "Nucleic acid delivery, siRNA conjugate, bioresponsive, endosomolytic peptide, melittin, IN-VIVO DELIVERY, GENE DELIVERY, RNA INTERFERENCE, PLASMID DNA, TUMOR, ACID, PEPTIDES, VECTORS, NANOPARTICLES, THERAPEUTICS",

author = "Martin Meyer and Christian Dohmen and Alexander Philipp and Daniel Kiener and Gelja Maiwald and Christina Scheu and Manfred Ogris and Ernst Wagner",

year = "2009",

doi = "10.1021/mp9000124",

language = "English",

volume = "6",

pages = "752--762",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

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TY - JOUR

T1 - Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate

AU - Meyer, Martin

AU - Dohmen, Christian

AU - Philipp, Alexander

AU - Kiener, Daniel

AU - Maiwald, Gelja

AU - Scheu, Christina

AU - Ogris, Manfred

AU - Wagner, Ernst

PY - 2009

Y1 - 2009

KW - Nucleic acid delivery

KW - siRNA conjugate

KW - bioresponsive

KW - endosomolytic peptide

KW - melittin

KW - IN-VIVO DELIVERY

KW - GENE DELIVERY

KW - RNA INTERFERENCE

KW - PLASMID DNA

KW - TUMOR

KW - ACID

KW - PEPTIDES

KW - VECTORS

KW - NANOPARTICLES

KW - THERAPEUTICS

U2 - 10.1021/mp9000124

DO - 10.1021/mp9000124

M3 - Article

SN - 1543-8384

VL - 6

SP - 752

EP - 762

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

IS - 3

ER -

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate

Funding

Austrian Fields of Science 2012

Keywords

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