Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A(1) (S44HP)

Maria N. Preobrazhenskaya, Eugenia N. Olsufyeva, Anna N. Tevyashova, Svetlana S. Printsevskaya, Svetlana E. Solovieva, Marina I. Reznikova, Aleksey S. Trenin, Olga A. Galatenko, Ivan D. Treshalin, Eleonora R. Pereverzeva, Elena P. Mirchink, Sergey B. Zotchev

    Publications: Contribution to journalArticlePeer Reviewed

    Original languageEnglish
    Pages (from-to)55-64
    Number of pages10
    JournalJournal of Antibiotics
    Volume63
    Issue number2
    DOIs
    Publication statusPublished - Feb 2010

    Austrian Fields of Science 2012

    • 104013 Natural product chemistry
    • 301207 Pharmaceutical chemistry

    Keywords

    • antifungal polyene macrolide antibiotic
    • genetically engineered polyene antibiotic 28, 29-didehydro nystatin A1
    • model of the candidosis sepsis
    • semi-synthetic macrolide antibiotics
    • AMPHOTERICIN-B
    • METHYL-ESTER
    • TOXICITY

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