TY - JOUR
T1 - Synthesis, cytotoxicity, and structure-activity relationships of new oxaliplatin derivatives
AU - Galanski, Mathea Sophia
AU - Yasemi, Afshin
AU - Jakupec, Michael
AU - Keyserlingk, Nikolai Graf v.
AU - Keppler, Bernhard
N1 - DOI: 10.1007/s00706-004-0241-3
Affiliations: Institute of Inorganic Chemistry, University of Vienna, A-1090 Vienna, Austria; Faustus Forschungs Co. T., D-04109 Leipzig, Germany
Adressen: Galanski, M.; Institute of Inorganic Chemistry; University of Vienna A-1090 Vienna, Austria; email: [email protected]
Source-File: ChemieErgScopus.csv
Import aus Scopus: 2-s2.0-18544389361
Importdatum: 09.01.2007 14:08:09
12.02.2008: Datenanforderung 2112 (Import Sachbearbeiter)
09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)
PY - 2005
Y1 - 2005
N2 - In order to setup structure-activity relationships and to explore the possibilities of improving the anticancer activity of oxaliplatin, which was recently approved for combination chemotherapy of metastatic colorectal cancer, new oxaliplatin analogues have been synthesized. The cytotoxicity was determined in nine human tumor cell lines and revealed a comparable or even higher cytotoxic potency in leukemia, ovarian and colon cancer cell lines in the case of small substituents at position 4 of the cyclohexane-1,2-diamine ligand. Introduction of bigger substituents at this position and thereby increasing the steric demand of the diamine ligands and the lipophilicity of the oxaliplatin derivatives resulted in platinum complexes with reduced cytotoxic properties. ΠSpringer-Verlag 2005.
AB - In order to setup structure-activity relationships and to explore the possibilities of improving the anticancer activity of oxaliplatin, which was recently approved for combination chemotherapy of metastatic colorectal cancer, new oxaliplatin analogues have been synthesized. The cytotoxicity was determined in nine human tumor cell lines and revealed a comparable or even higher cytotoxic potency in leukemia, ovarian and colon cancer cell lines in the case of small substituents at position 4 of the cyclohexane-1,2-diamine ligand. Introduction of bigger substituents at this position and thereby increasing the steric demand of the diamine ligands and the lipophilicity of the oxaliplatin derivatives resulted in platinum complexes with reduced cytotoxic properties. ΠSpringer-Verlag 2005.
M3 - Article
SN - 0026-9247
VL - 136
SP - 693
EP - 700
JO - Monatshefte für Chemie
JF - Monatshefte für Chemie
IS - 5
ER -
