Abstract
We describe the single-step formation of complex tetracyclic fused scaffolds enabled by (3 + 2) cycloaddition of azomethine ylides. Various indoles, N-protecting groups, and amino acids are well tolerated. The products are obtained in a catalyst-free manner with moderate to excellent yield and high diastereoselectivity. Representing a new scaffold that is not yet found in nature, the construction of pyrrolidine-fused cyclohepta-, azepino-, or oxepinoindoles could be found valuable in the synthesis of new pseudo-natural products.
Original language | English |
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Pages (from-to) | 4873-4876 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 26 |
Issue number | 23 |
Early online date | 2024 |
DOIs | |
Publication status | Published - 14 Jun 2024 |
Austrian Fields of Science 2012
- 104015 Organic chemistry
- 301207 Pharmaceutical chemistry