Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors

Franco Chimenti; Daniela Secci; Adriana Bolasco; Paola Chimenti; Arianna Granese; Simone Carradori; Elias Maccioni; M. Cristina Cardia; Matilde Yanez; Francisco Orallo; Stefano Alcaro; Francesco Ortuso; Roberto Cirilli; Rosella Ferretti; Simona Distinto; Johannes Kirchmair; Thierry Langer

doi:10.1016/j.bmc.2010.05.070

Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors

Franco Chimenti, Daniela Secci, Adriana Bolasco, Paola Chimenti, Arianna Granese, Simone Carradori, Elias Maccioni, M. Cristina Cardia, Matilde Yanez, Francisco Orallo, Stefano Alcaro, Francesco Ortuso, Roberto Cirilli, Rosella Ferretti, Simona Distinto, Johannes Kirchmair, Thierry Langer

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	5063-5070
Number of pages	8
Journal	Bioorganic & Medicinal Chemistry
Volume	18
Issue number	14
DOIs	https://doi.org/10.1016/j.bmc.2010.05.070
Publication status	Published - 15 Jul 2010
Externally published	Yes

Funding

This work was supported by MURST (Italy), Ministerio de Sanidad y Consumo (Spain; FISS PI061537) and Xunta de Galicia (Spain; INCITE07PXI203039ES, INCITE08E1R203054ES, and 08CSA019 203PR).

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

Hydrazothiazole derivatives
3D-QSAR
Human monoamine oxidase B inhibitors
PHARMACOPHORE-BASED ALIGNMENT
PARKINSONS-DISEASE
THIAZOLE DERIVATIVES
MAO-B
VALIDATION
HYDRAZINES
BINDING
FIELD
GENE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bmc.2010.05.070

Cite this

Chimenti, F., Secci, D., Bolasco, A., Chimenti, P., Granese, A., Carradori, S., Maccioni, E., Cardia, M. C., Yanez, M., Orallo, F., Alcaro, S., Ortuso, F., Cirilli, R., Ferretti, R., Distinto, S., Kirchmair, J., & Langer, T. (2010). Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorganic & Medicinal Chemistry, 18(14), 5063-5070. https://doi.org/10.1016/j.bmc.2010.05.070

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title = "Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors",

keywords = "Hydrazothiazole derivatives, 3D-QSAR, Human monoamine oxidase B inhibitors, PHARMACOPHORE-BASED ALIGNMENT, PARKINSONS-DISEASE, THIAZOLE DERIVATIVES, MAO-B, VALIDATION, HYDRAZINES, BINDING, FIELD, GENE",

author = "Franco Chimenti and Daniela Secci and Adriana Bolasco and Paola Chimenti and Arianna Granese and Simone Carradori and Elias Maccioni and Cardia, \{M. Cristina\} and Matilde Yanez and Francisco Orallo and Stefano Alcaro and Francesco Ortuso and Roberto Cirilli and Rosella Ferretti and Simona Distinto and Johannes Kirchmair and Thierry Langer",

year = "2010",

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day = "15",

doi = "10.1016/j.bmc.2010.05.070",

language = "English",

volume = "18",

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journal = "Bioorganic \& Medicinal Chemistry",

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Chimenti, F, Secci, D, Bolasco, A, Chimenti, P, Granese, A, Carradori, S, Maccioni, E, Cardia, MC, Yanez, M, Orallo, F, Alcaro, S, Ortuso, F, Cirilli, R, Ferretti, R, Distinto, S, Kirchmair, J & Langer, T 2010, 'Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors', Bioorganic & Medicinal Chemistry, vol. 18, no. 14, pp. 5063-5070. https://doi.org/10.1016/j.bmc.2010.05.070

TY - JOUR

T1 - Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors

AU - Chimenti, Franco

AU - Secci, Daniela

AU - Bolasco, Adriana

AU - Chimenti, Paola

AU - Granese, Arianna

AU - Carradori, Simone

AU - Maccioni, Elias

AU - Cardia, M. Cristina

AU - Yanez, Matilde

AU - Orallo, Francisco

AU - Alcaro, Stefano

AU - Ortuso, Francesco

AU - Cirilli, Roberto

AU - Ferretti, Rosella

AU - Distinto, Simona

AU - Kirchmair, Johannes

AU - Langer, Thierry

PY - 2010/7/15

Y1 - 2010/7/15

KW - Hydrazothiazole derivatives

KW - 3D-QSAR

KW - Human monoamine oxidase B inhibitors

KW - PHARMACOPHORE-BASED ALIGNMENT

KW - PARKINSONS-DISEASE

KW - THIAZOLE DERIVATIVES

KW - MAO-B

KW - VALIDATION

KW - HYDRAZINES

KW - BINDING

KW - FIELD

KW - GENE

U2 - 10.1016/j.bmc.2010.05.070

DO - 10.1016/j.bmc.2010.05.070

M3 - Article

SN - 0968-0896

VL - 18

SP - 5063

EP - 5070

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

IS - 14

ER -

Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors

Funding

Austrian Fields of Science 2012

Keywords

UN SDGs

Access to Document

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Cite this