TY - JOUR
T1 - Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine 4N-dimethylthiosemicarbazone
AU - Arion, Vladimir
AU - Jakupec, Michael
AU - Galanski, Mathea Sophia
AU - Unfried, Peter
AU - Keppler, Bernhard
N1 - Zeitschrift: Journal of Inorganic Biochemistry
DOI: 10.1016/S0162-0134(02)00419-1
Coden: JIBID
Affiliations: Institute of Inorganic Chemistry, University of Vienna, Waehringerstr. 42, A-1090 Vienna, Austria
Adressen: Keppler, B.K.; Institute of Inorganic Chemistry; University of Vienna; Waehringerstr. 42 A-1090 Vienna, Austria; email: [email protected]
Source-File: ChemieErgScopus.csv
Import aus Scopus: 2-s2.0-0037173568
Importdatum: 09.01.2007 14:12:23
12.02.2008: Datenanforderung 2112 (Import Sachbearbeiter)
09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)
PY - 2002
Y1 - 2002
N2 - The reaction of 2-acetylpyridine 4N-dimethylthiosemicarbazone (HL) with GaCl3 in absolute ethanol in 1:1 molar ratio yielded the complex [GaL2][GaCl4]. The crystal structure of the gallium(III) complex has been determined by X-ray diffraction methods. Infrared, electronic, ESI mass and 1H, 13C, 15N and 71Ga NMR spectra, as well as the thermal behaviour are reported. The cytotoxicity assay in several human cancer cell lines (SW480, SK-BR-3 and 41M) suggests that the gallium(III) complex might be endowed with promising antitumour properties. In vitro cytotoxic activity exceeds that of all other tested gallium(III) complexes and is slightly higher than that of HL. Copyright Π2002 .
AB - The reaction of 2-acetylpyridine 4N-dimethylthiosemicarbazone (HL) with GaCl3 in absolute ethanol in 1:1 molar ratio yielded the complex [GaL2][GaCl4]. The crystal structure of the gallium(III) complex has been determined by X-ray diffraction methods. Infrared, electronic, ESI mass and 1H, 13C, 15N and 71Ga NMR spectra, as well as the thermal behaviour are reported. The cytotoxicity assay in several human cancer cell lines (SW480, SK-BR-3 and 41M) suggests that the gallium(III) complex might be endowed with promising antitumour properties. In vitro cytotoxic activity exceeds that of all other tested gallium(III) complexes and is slightly higher than that of HL. Copyright Π2002 .
U2 - 10.1016/S0162-0134(02)00419-1
DO - 10.1016/S0162-0134(02)00419-1
M3 - Meeting abstract/Conference paper
SN - 0162-0134
VL - 91
SP - 298
EP - 305
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 1
ER -
