Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide

Funding

Support was provided by the National Institutes of Health (R35 GM122606, R.A.S.; P60 AA006420 and AA015566, M.R.), Jiangsu Industrial Technology Research Institute (M.A.B.), the Uehara Memorial Foundation (M.O.), and the National Science Foundation (CHE-1955922, R.A.S; CHE1764328, K.N.H). Calculations were performed on the Hoffman2 cluster at the University of California, Los Angeles, and the Extreme Science and Engineering Discovery Environment (XSEDE), supported by the National Science Foundation (OCI-1053575). C.C.L. is grateful to the Imperial College Bursary Scheme for funding. We thank Dr. Jason S. Chen and Brittany Sanchez of the Scripps Automated Synthesis Facility for help with separations and analysis. We gratefully acknowledge Brandon Wright, Robert Lusi, and Professor Richmond Sarpong for beta-testing the Bo<spacing diaeresis>ttcher score code and Professor Bo<spacing diaeresis>ttcher for helpful correspondence.