Systematic Comparison of Advanced Network Analysis and Visualization of Lipidomics Data

Jana Schwarzerová (Corresponding author), Dominika Olešová (Corresponding author), Aleš Kvasnička, David Friedecký, Margaret Varga, Valentine Provazník, Wolfram Weckwerth

Publications: Contribution to bookContribution to proceedingsPeer Reviewed

Abstract

Comprehensive analysis of lipids is becoming a forefront of clinical data analysis. Due to significant technical advancements, lipidomics is emerging in clinical diagnostics for improvement and earlier detection of a broad range of diseases. However, in order to understand the biological complexities and interrelationships between the molecules, it is important to have a correct representation of the data and visualizations that enable good interpretability of the lipidomic data. Therefore, the present study systematically compares different visualization methods for lipidomic data, based on different computational relations between the selected lipids and supplemented with known biological information. Networks were reconstructed, and an analysis was performed to objectively compare the visualizations.

Original languageEnglish
Title of host publicationBioinformatics and Biomedical Engineering - 10th International Work-Conference, IWBBIO 2023, Proceedings
EditorsIgnacio Rojas, Olga Valenzuela, Fernando Rojas Ruiz, Luis Javier Herrera, Francisco Ortuño
PublisherSpringer Science and Business Media Deutschland GmbH
Pages378-389
Number of pages12
ISBN (Print)9783031349522
DOIs
Publication statusPublished - 23 Jun 2023
Event10th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2023 - Meloneras, Spain
Duration: 12 Jul 202314 Jul 2023

Publication series

SeriesLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume13919 LNBI
ISSN0302-9743

Conference

Conference10th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2023
Country/TerritorySpain
CityMeloneras
Period12/07/2314/07/23

Austrian Fields of Science 2012

  • 301302 Lipidomics research
  • 106005 Bioinformatics

Keywords

  • Comprehensive Analysis
  • Lipids
  • Network Visualization
  • Networks Analysis

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