Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb
            III}
            4(A-α-XW
            9O
            34)
            2]
            n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity

Tian Ma; Peng Yang; Inga Dammann; Zhengguo Lin; Ali S. Mougharbel; Ming-Xing Li; Florin Adasalitei; Raluca Mitea; Cristian Silvestru; Candice Thorstenson; Matthias S. Ullrich; Klaudia Cseh; Michael A. Jakupec; Bernhard K. Keppler; Manuela Donalisio; Roberta Cavalli; David Lembo; Ulrich Kortz

doi:10.1021/acs.inorgchem.9b03322

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity

Tian Ma
, Peng Yang
, Inga Dammann
, Zhengguo Lin
, Ali S. Mougharbel
, Ming-Xing Li
, Florin Adasalitei
, Raluca Mitea
, Cristian Silvestru
, Candice Thorstenson
, Matthias S. Ullrich
, Klaudia Cseh
, Michael A. Jakupec
, Bernhard K. Keppler
, Manuela Donalisio
, Roberta Cavalli
, David Lembo
, Ulrich Kortz (Corresponding author)

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)Sb III} 4(A-α-XW 9O 34) 2] n- [X = P V (1-P), As V (1-As), or Ge IV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).

Original language	English
Pages (from-to)	2978-2987
Number of pages	10
Journal	Inorganic Chemistry
Volume	59
Issue number	5
DOIs	https://doi.org/10.1021/acs.inorgchem.9b03322
Publication status	Published - 2 Mar 2020

Funding

U.K. thanks the German Science Foundation (DFG-K0-2288/20-1 and DFG-KO-2288/26-1) and Jacobs University for research support. T.M. and P.Y. acknowledge the China Scholarship Council (CSC) for a doctoral fellowship. Z.L. thanks the National Natural Science Foundation of China (21701010) for research support. F.A., R.M., and C.S. gratefully acknowledge the financial support from the National Research Council (CNCS) of Romania, through Research Project PN-II-ID-PCE-2011-3-0933. U.K also acknowledges CMST COST Action CM1203 (PoCheMoN). Figure 1 was generated with Diamond, version 3.2 (Crystal Impact GbR).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

104003 Inorganic chemistry

Keywords

DAWSON POLYOXOMETALATE
ORGANOPHOSPHORYL POLYOXOTUNGSTATES
ORGANOSILYL DERIVATIVES
ARYLSTIBONIC ACIDS
CRYSTAL-STRUCTURES
GENERAL FORMULA
HETEROPOLYANIONS
FUNCTIONALIZATION
ORGANOTIN
HYBRIDS

Access to Document

10.1021/acs.inorgchem.9b03322

Cite this

Ma, T., Yang, P., Dammann, I., Lin, Z., Mougharbel, A. S., Li, M.-X., Adasalitei, F., Mitea, R., Silvestru, C., Thorstenson, C., Ullrich, M. S., Cseh, K., Jakupec, M. A., Keppler, B. K., Donalisio, M., Cavalli, R., Lembo, D., & Kortz, U. (2020). Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity. Inorganic Chemistry, 59(5), 2978-2987. https://doi.org/10.1021/acs.inorgchem.9b03322

Ma, Tian ; Yang, Peng ; Dammann, Inga et al. / Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge) : Synthesis, Structure, and Study of Antibacterial and Antitumor Activity. In: Inorganic Chemistry. 2020 ; Vol. 59, No. 5. pp. 2978-2987.

@article{5e5c9fb1ff094c6aa1095d20054307a6,

title = "Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [\{(p-tolyl)Sb III\} 4(A-α-XW 9O 34) 2] n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity",

abstract = "We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [\{(p-tolyl)Sb III\} 4(A-α-XW 9O 34) 2] n- [X = P V (1-P), As V (1-As), or Ge IV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma). ",

keywords = "DAWSON POLYOXOMETALATE, ORGANOPHOSPHORYL POLYOXOTUNGSTATES, ORGANOSILYL DERIVATIVES, ARYLSTIBONIC ACIDS, CRYSTAL-STRUCTURES, GENERAL FORMULA, HETEROPOLYANIONS, FUNCTIONALIZATION, ORGANOTIN, HYBRIDS",

author = "Tian Ma and Peng Yang and Inga Dammann and Zhengguo Lin and Mougharbel, \{Ali S.\} and Ming-Xing Li and Florin Adasalitei and Raluca Mitea and Cristian Silvestru and Candice Thorstenson and Ullrich, \{Matthias S.\} and Klaudia Cseh and Jakupec, \{Michael A.\} and Keppler, \{Bernhard K.\} and Manuela Donalisio and Roberta Cavalli and David Lembo and Ulrich Kortz",

note = "Accession Number: WOS:000518088800041 PubMed ID: 32037809 ",

year = "2020",

month = mar,

day = "2",

doi = "10.1021/acs.inorgchem.9b03322",

language = "English",

volume = "59",

pages = "2978--2987",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "AMER CHEMICAL SOC",

number = "5",

}

Ma, T, Yang, P, Dammann, I, Lin, Z, Mougharbel, AS, Li, M-X, Adasalitei, F, Mitea, R, Silvestru, C, Thorstenson, C, Ullrich, MS, Cseh, K, Jakupec, MA , Keppler, BK, Donalisio, M, Cavalli, R, Lembo, D & Kortz, U 2020, 'Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity', Inorganic Chemistry, vol. 59, no. 5, pp. 2978-2987. https://doi.org/10.1021/acs.inorgchem.9b03322

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity. / Ma, Tian; Yang, Peng; Dammann, Inga et al.
In: Inorganic Chemistry, Vol. 59, No. 5, 02.03.2020, p. 2978-2987.

Publications: Contribution to journal › Article › Peer Reviewed

TY - JOUR

T1 - Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb III} 4(A-α-XW 9O 34) 2] n- (X = P, As, or Ge)

T2 - Synthesis, Structure, and Study of Antibacterial and Antitumor Activity

AU - Ma, Tian

AU - Yang, Peng

AU - Dammann, Inga

AU - Lin, Zhengguo

AU - Mougharbel, Ali S.

AU - Li, Ming-Xing

AU - Adasalitei, Florin

AU - Mitea, Raluca

AU - Silvestru, Cristian

AU - Thorstenson, Candice

AU - Ullrich, Matthias S.

AU - Cseh, Klaudia

AU - Jakupec, Michael A.

AU - Keppler, Bernhard K.

AU - Donalisio, Manuela

AU - Cavalli, Roberta

AU - Lembo, David

AU - Kortz, Ulrich

N1 - Accession Number: WOS:000518088800041 PubMed ID: 32037809

PY - 2020/3/2

Y1 - 2020/3/2

N2 - We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)Sb III} 4(A-α-XW 9O 34) 2] n- [X = P V (1-P), As V (1-As), or Ge IV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).

AB - We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)Sb III} 4(A-α-XW 9O 34) 2] n- [X = P V (1-P), As V (1-As), or Ge IV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).

KW - DAWSON POLYOXOMETALATE

KW - ORGANOPHOSPHORYL POLYOXOTUNGSTATES

KW - ORGANOSILYL DERIVATIVES

KW - ARYLSTIBONIC ACIDS

KW - CRYSTAL-STRUCTURES

KW - GENERAL FORMULA

KW - HETEROPOLYANIONS

KW - FUNCTIONALIZATION

KW - ORGANOTIN

KW - HYBRIDS

UR - https://www.scopus.com/pages/publications/85079769832

U2 - 10.1021/acs.inorgchem.9b03322

DO - 10.1021/acs.inorgchem.9b03322

M3 - Article

SN - 0020-1669

VL - 59

SP - 2978

EP - 2987

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 5

ER -

Ma T, Yang P, Dammann I, Lin Z, Mougharbel AS, Li MX et al. Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity. Inorganic Chemistry. 2020 Mar 2;59(5):2978-2987. doi: 10.1021/acs.inorgchem.9b03322

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity

Abstract

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

Other files and links

Fingerprint

Cite this

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb III} 4(A-α-XW 9O 34) 2] n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity

Abstract

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

Other files and links

Fingerprint

Cite this

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb ^III} ₄(A-α-XW ₉O ₃₄) ₂] ^n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity