The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

M. P. Sullivan; H. U. Holtkamp; S. M. Meier; C. G. Hartinger

doi:10.1016/B978-0-12-803814-7.00010-1

The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

M. P. Sullivan (Corresponding author), H. U. Holtkamp, S. M. Meier, C. G. Hartinger

Department of Analytical Chemistry

Publications: Contribution to book › Chapter › Peer Reviewed

Abstract

The mode of action of medically relevant coordination and organometallic compounds in a biological environment is crucially dependent on their interactions with biological molecules. Since the discovery of cisplatin, a wide variety of metal complexes have been designed for the treatment of cancer and other diseases as well as for diagnostic purposes. In this chapter, we review the binding events inorganic compounds undergo from administration to the biological target with a special emphasis on the strengths and weaknesses of the methods employed for these studies. We have focused on compounds that are at an advanced preclinical development stage, undergo clinical trials or are in clinical use.

Original language	English
Title of host publication	Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells
Publisher	Elsevier
Pages	355-386
Number of pages	32
ISBN (Electronic)	9780128038871
ISBN (Print)	9780128038147
DOIs	https://doi.org/10.1016/B978-0-12-803814-7.00010-1
Publication status	Published - 6 Jan 2017

Austrian Fields of Science 2012

104003 Inorganic chemistry
104002 Analytical chemistry
301904 Cancer research

Keywords

Analytical methods
Cancer chemotherapy
Coordination complexes
DNA
Metallomics
Organometallic compounds
Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-803814-7.00010-1

Cite this

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AU - Meier, S. M.

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AB - The mode of action of medically relevant coordination and organometallic compounds in a biological environment is crucially dependent on their interactions with biological molecules. Since the discovery of cisplatin, a wide variety of metal complexes have been designed for the treatment of cancer and other diseases as well as for diagnostic purposes. In this chapter, we review the binding events inorganic compounds undergo from administration to the biological target with a special emphasis on the strengths and weaknesses of the methods employed for these studies. We have focused on compounds that are at an advanced preclinical development stage, undergo clinical trials or are in clinical use.

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KW - DNA

KW - Metallomics

KW - Organometallic compounds

KW - Proteins

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SN - 9780128038147

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BT - Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

PB - Elsevier

ER -

The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

Abstract

Austrian Fields of Science 2012

Keywords

UN SDGs

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