The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation

Dina Baier, Beatrix Schönhacker-Alte, Mate Rusz, Christine Pirker, Thomas Mohr, Theresa Mendrina, Dominik Kirchhofer, Samuel M. Meier-Menches, Katharina Hohenwallner, Martin Schaier, Evelyn Rampler, Gunda Koellensperger, Petra Heffeter, Bernhard Keppler, Walter Berger (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Article number238
Number of pages27
JournalPharmaceutics
Volume14
Issue number2
DOIs
Publication statusPublished - 20 Jan 2022

Austrian Fields of Science 2012

  • 301209 Pharmacy
  • 301206 Pharmacology

Keywords

  • BOLD-100
  • KP1339
  • ruthenium
  • chemotherapy resistance
  • 2-deoxy-d-glucose
  • glycolysis
  • ER stress
  • autophagy
  • lysosome
  • colon cancer
  • pancreatic cancer
  • CELL LUNG-CANCER
  • ENERGY-METABOLISM
  • PROSTATE-CANCER
  • 2-DEOXY-D-GLUCOSE
  • EXPRESSION
  • 2-DEOXYGLUCOSE
  • AUTOPHAGY
  • DRUG
  • SUPPRESSES
  • RESISTANCE
  • Lysosome
  • Autophagy
  • Colon cancer
  • 2-deoxy-D-glucose
  • Chemotherapy resistance
  • Ruthenium
  • BOLD-100/KP1339
  • Pancreatic cancer
  • Glycolysis

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