The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties

Georg Aichinger, Falk-Bach Lichtenberger, Tamara N. Steinhauer, Inken Floerkemeier, Giorgia Del Favero, Bernd Clement, Doris Marko (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Article number1524
Number of pages11
JournalMolecules
Volume25
Issue number7
DOIs
Publication statusPublished - Apr 2020

Austrian Fields of Science 2012

  • 106002 Biochemistry
  • 106023 Molecular biology
  • 301211 Toxicology

Keywords

  • chemotherapy
  • drug development
  • topoisomerase poisoning
  • dual topoisomerase inhibitor
  • genotoxicity
  • nuclear localization
  • confocal microscopy
  • DNA TOPOISOMERASES
  • ANTICANCER
  • INHIBITORS
  • CELLS
  • COMPLEXES
  • COLON
  • Nuclear localization
  • Genotoxicity
  • Confocal microscopy
  • Drug development
  • Dual topoisomerase inhibitor
  • Chemotherapy
  • Topoisomerase poisoning

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