The Emergence and Impact of the M1UK Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand

Anna Vesty; Xiaoyun Ren; Prachi Sharma; Natalie Lorenz; Thomas Proft; Allan Hardaker; Christina Straub; Julie Morgan; Audrey Tiong; Anneka Anderson; Rachel H. Webb; Julie Bennett; Philip E. Carter; Nicole J. Moreland

doi:10.1093/ofid/ofae457

The Emergence and Impact of the M1_UK Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand

Anna Vesty, Xiaoyun Ren, Prachi Sharma, Natalie Lorenz, Thomas Proft, Allan Hardaker, Christina Straub (Corresponding author), Julie Morgan, Audrey Tiong, Anneka Anderson, Rachel H. Webb, Julie Bennett, Philip E. Carter, Nicole J. Moreland (Corresponding author)

Department of Microbiology and Ecosystem Science

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

M1_UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1_UK is now the dominant invasive emm1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A Streptococcus pharyngitis in children could reduce invasive disease.

Original language	English
Article number	ofae457
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	11
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofae457
Publication status	Published - 9 Aug 2024

Austrian Fields of Science 2012

106026 Ecosystem research
106022 Microbiology

Keywords

emm1
group A streptococcus
invasive group A streptococcal disease
M1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/ofid/ofae457Licence: CC BY-NC-ND 4.0

Cite this

Vesty, A., Ren, X., Sharma, P., Lorenz, N., Proft, T., Hardaker, A., Straub, C., Morgan, J., Tiong, A., Anderson, A., Webb, R. H., Bennett, J., Carter, P. E., & Moreland, N. J. (2024). The Emergence and Impact of the M1_UK Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand. Open Forum Infectious Diseases, 11(8), Article ofae457. https://doi.org/10.1093/ofid/ofae457

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abstract = "M1UK is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1UK is now the dominant invasive emm1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A Streptococcus pharyngitis in children could reduce invasive disease.",

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author = "Anna Vesty and Xiaoyun Ren and Prachi Sharma and Natalie Lorenz and Thomas Proft and Allan Hardaker and Christina Straub and Julie Morgan and Audrey Tiong and Anneka Anderson and Webb, {Rachel H.} and Julie Bennett and Carter, {Philip E.} and Moreland, {Nicole J.}",

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AU - Lorenz, Natalie

AU - Proft, Thomas

AU - Hardaker, Allan

AU - Straub, Christina

AU - Morgan, Julie

AU - Tiong, Audrey

AU - Anderson, Anneka

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AU - Carter, Philip E.

AU - Moreland, Nicole J.

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