The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Tim Brecklinghaus, Wiebke Albrecht, Franziska Kappenberg, Julia Duda, Nachiket Vartak, Karolina Edlund, Rosemarie Marchan, Ahmed Ghallab, Cristina Cadenas, Georgia Günther, Marcel Leist, Mian Zhang, Iain Gardner, Jörg Reinders, Frans GM Russel, Alison J. Foster, Dominic P. Williams, Amruta Damle-Vartak, Melanie Grandits, Gerhard EckerNaim Kittana, Jörg Rahnenführer, Jan G. Hengstler

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Article number109728
Number of pages16
JournalChemico-Biological Interactions
Volume351
DOIs
Publication statusPublished - 5 Jan 2022

Austrian Fields of Science 2012

  • 301207 Pharmaceutical chemistry

Keywords

  • Cholestasis
  • DILI
  • Transport
  • IN-VITRO
  • TRANSPORTER
  • GLUTATHIONE
  • LIVER
  • Cell Culture Techniques/methods
  • Humans
  • Cells, Cultured
  • Cytotoxins/toxicity
  • Hepatocytes/drug effects
  • Toxicity Tests/methods
  • Fluoresceins/metabolism
  • Multidrug Resistance-Associated Protein 2/antagonists & inhibitors
  • ATP Binding Cassette Transporter, Subfamily B, Member 11/antagonists & inhibitors
  • Mitochondria/drug effects
  • Chemical and Drug Induced Liver Injury

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