The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

Jana Flegel; Saad Shaaban; Zhi Jun Jia; Britta Schulte; Yilong Lian; Adrian Krzyzanowski; Malte Metz; Tabea Schneidewind; Fabian Wesseler; Anke Flegel; Alisa Reich; Alexandra Brause; Gang Xue; Minghao Zhang; Lara Doetsch; Isabelle D. Stender; Jan -Erik Hoffmann; Rebecca Scheel; Petra Janning; Fraydoon Rastinejad; Dennis Schade; Carsten Strohmann; Andrey P. Antonchick; Sonja Sievers; Pedro Moura-Alves; Slava Ziegler; Herbert Waldmann

doi:10.1021/acs.jmedchem.2c00956

The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

Jana Flegel, Saad Shaaban, Zhi Jun Jia, Britta Schulte, Yilong Lian, Adrian Krzyzanowski, Malte Metz, Tabea Schneidewind, Fabian Wesseler, Anke Flegel, Alisa Reich, Alexandra Brause, Gang Xue, Minghao Zhang, Lara Doetsch, Isabelle D. Stender, Jan -Erik Hoffmann, Rebecca Scheel, Petra Janning, Fraydoon RastinejadDennis Schade, Carsten Strohmann, Andrey P. Antonchick, Sonja Sievers, Pedro Moura-Alves, Slava Ziegler, Herbert Waldmann (Corresponding author)

Department of Organic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	16268-16289
Number of pages	22
Journal	Journal of Medicinal Chemistry
Volume	65
Issue number	24
DOIs	https://doi.org/10.1021/acs.jmedchem.2c00956
Publication status	Published - Dec 2022

Austrian Fields of Science 2012

301306 Medical molecular biology
301305 Medical chemistry
301304 Medical biology

Keywords

LIGAND BINDING DOMAIN
3-DIMENSIONAL STRUCTURES
ASSAY INTERFERENCE
PROTEIN
IDENTIFICATION
MODEL
PROTOBERBERINE
RECOGNITION
ACTIVATION
MECHANISMS

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Flegel, J., Shaaban, S., Jia, Z. J., Schulte, B., Lian, Y., Krzyzanowski, A., Metz, M., Schneidewind, T., Wesseler, F., Flegel, A., Reich, A., Brause, A., Xue, G., Zhang, M., Doetsch, L., Stender, I. D., Hoffmann, J. .-E., Scheel, R., Janning, P., ... Waldmann, H. (2022). The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. Journal of Medicinal Chemistry, 65(24), 16268-16289. https://doi.org/10.1021/acs.jmedchem.2c00956

@article{ff28c72432234704a919ca0bf763a900,

title = "The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation",

keywords = "LIGAND BINDING DOMAIN, 3-DIMENSIONAL STRUCTURES, ASSAY INTERFERENCE, PROTEIN, IDENTIFICATION, MODEL, PROTOBERBERINE, RECOGNITION, ACTIVATION, MECHANISMS",

author = "Jana Flegel and Saad Shaaban and Jia, {Zhi Jun} and Britta Schulte and Yilong Lian and Adrian Krzyzanowski and Malte Metz and Tabea Schneidewind and Fabian Wesseler and Anke Flegel and Alisa Reich and Alexandra Brause and Gang Xue and Minghao Zhang and Lara Doetsch and Stender, {Isabelle D.} and Hoffmann, {Jan -Erik} and Rebecca Scheel and Petra Janning and Fraydoon Rastinejad and Dennis Schade and Carsten Strohmann and Antonchick, {Andrey P.} and Sonja Sievers and Pedro Moura-Alves and Slava Ziegler and Herbert Waldmann",

note = "Accession Number: WOS:000905329900001 PubMed ID: 36459434",

year = "2022",

month = dec,

doi = "10.1021/acs.jmedchem.2c00956",

language = "English",

volume = "65",

pages = "16268--16289",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "AMER CHEMICAL SOC",

number = "24",

}

Flegel, J, Shaaban, S, Jia, ZJ, Schulte, B, Lian, Y, Krzyzanowski, A, Metz, M, Schneidewind, T, Wesseler, F, Flegel, A, Reich, A, Brause, A, Xue, G, Zhang, M, Doetsch, L, Stender, ID, Hoffmann, J-E, Scheel, R, Janning, P, Rastinejad, F, Schade, D, Strohmann, C, Antonchick, AP, Sievers, S, Moura-Alves, P, Ziegler, S & Waldmann, H 2022, 'The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation', Journal of Medicinal Chemistry, vol. 65, no. 24, pp. 16268-16289. https://doi.org/10.1021/acs.jmedchem.2c00956

TY - JOUR

T1 - The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

AU - Flegel, Jana

AU - Shaaban, Saad

AU - Jia, Zhi Jun

AU - Schulte, Britta

AU - Lian, Yilong

AU - Krzyzanowski, Adrian

AU - Metz, Malte

AU - Schneidewind, Tabea

AU - Wesseler, Fabian

AU - Flegel, Anke

AU - Reich, Alisa

AU - Brause, Alexandra

AU - Xue, Gang

AU - Zhang, Minghao

AU - Doetsch, Lara

AU - Stender, Isabelle D.

AU - Hoffmann, Jan -Erik

AU - Scheel, Rebecca

AU - Janning, Petra

AU - Rastinejad, Fraydoon

AU - Schade, Dennis

AU - Strohmann, Carsten

AU - Antonchick, Andrey P.

AU - Sievers, Sonja

AU - Moura-Alves, Pedro

AU - Ziegler, Slava

AU - Waldmann, Herbert

N1 - Accession Number: WOS:000905329900001 PubMed ID: 36459434

PY - 2022/12

Y1 - 2022/12

KW - LIGAND BINDING DOMAIN

KW - 3-DIMENSIONAL STRUCTURES

KW - ASSAY INTERFERENCE

KW - PROTEIN

KW - IDENTIFICATION

KW - MODEL

KW - PROTOBERBERINE

KW - RECOGNITION

KW - ACTIVATION

KW - MECHANISMS

UR - http://www.scopus.com/inward/record.url?scp=85143525772&partnerID=8YFLogxK

U2 - 10.1021/acs.jmedchem.2c00956

DO - 10.1021/acs.jmedchem.2c00956

M3 - Article

SN - 0022-2623

VL - 65

SP - 16268

EP - 16289

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 24

ER -

The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

Austrian Fields of Science 2012

Keywords

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