The intramolecular ligand-exchange reaction of (SP-4-2)-dichlorobis-(2-hydroxyethylamine)platinum(II) and (OC-6-22)-tetrachlorobis-(2-hydroxyethylamine)platinum(IV), a 1H and 15N,1H-HMQC NMR study

The bis(ethanolamine)platinum complexes (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) (1) and (OC-6-22)-tetrachlororbis(2-hydroxyethylamine)platinum(IV) (2) have been synthesized and their chemistry in aqueous solution has been investigated due to the fact that 1 forms very stable monoadducts with 5'-GMP. In water 1 and 2 are converted into (SP-4-3)-chloro(2-ethanolatoamine-? 2N,O)(2-hydroxy-ethylamine)platinum(II) (3) and (OC-6-31)-trichloro(2-ethanolatoamine-? 2N,O)(2-hydroxyethylamine)platinum(IV) (4) with a chelating ethanolatoamine ligand by a intramolecular ligand exchange reaction, which was confirmed by 1H and 2D 15N,1H-HMQC NMR experiments and the crystal structure determination of 4. ΠWiley-VCH Verlag GmbH, 2001.