The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding

Renee A. Rotolo; Vladimir Dragacevic; Predrag Kalaba; Ernst Urban; Martin Zehl; Alexander Roller; Judith Wackerlig; Thierry Langer; Marco Pistis; Maria Antonietta De Luca; Francesca Caria; Rebecca Schwartz; Rose E. Presby; Jen-Hau Yang; Shanna Samels; Merce Correa; Gert Lubec; John D. Salamone

doi:10.3389/fphar.2019.00682

The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding

Renee A. Rotolo
, Vladimir Dragacevic
, Predrag Kalaba
, Ernst Urban
, Martin Zehl
, Alexander Roller
, Judith Wackerlig
, Thierry Langer
, Marco Pistis
, Maria Antonietta De Luca
, Francesca Caria
, Rebecca Schwartz
, Rose E. Presby
, Jen-Hau Yang
, Shanna Samels
, Merce Correa
, Gert Lubec (Corresponding author)
, John D. Salamone (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	682
Number of pages	12
Journal	Frontiers in Pharmacology
Volume	10
DOIs	https://doi.org/10.3389/fphar.2019.00682
Publication status	Published - 28 Jun 2019

Funding

This work was supported by grants to JS from the University of Connecticut Research Foundation, to RS from the Connecticut Institute for Brain and Cognitive Sciences and the Summer Undergraduate Research Fund at the University of Connecticut, and to SS from the University of Connecticut Psychological Sciences Department. MADL was supported by Fondazione di Sardegna (Esercizio finanziario 2017), FIR 2019, Fondo di Sviluppo e Coesione 2014-2020(Project RASSR03071; CUP F76C18000830002).

Austrian Fields of Science 2012

301209 Pharmacy
301206 Pharmacology

Keywords

dopamine
transport
synthesis
motivation
depression
fatigue
anergia
modafinil
MAJOR DEPRESSIVE DISORDER
DECISION-MAKING
MESOLIMBIC DOPAMINE
NUCLEUS-ACCUMBENS
CHOICE BEHAVIOR
MOTIVATIONAL SYMPTOMS
ADENOSINE A(2A)
ACUTE STRESS
COCAINE
MODAFINIL
Synthesis
Motivation
Dopamine
Depression
Fatigue
Anergia
Modafinil
Transport

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10.3389/fphar.2019.00682Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1146428Licence: CC BY 4.0

Cite this

Rotolo, R. A., Dragacevic, V., Kalaba, P., Urban, E., Zehl, M., Roller, A., Wackerlig, J., Langer, T., Pistis, M., De Luca, M. A., Caria, F., Schwartz, R., Presby, R. E., Yang, J.-H., Samels, S., Correa, M., Lubec, G., & Salamone, J. D. (2019). The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Frontiers in Pharmacology, 10, Article 682. https://doi.org/10.3389/fphar.2019.00682

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title = "The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding",

keywords = "dopamine, transport, synthesis, motivation, depression, fatigue, anergia, modafinil, MAJOR DEPRESSIVE DISORDER, DECISION-MAKING, MESOLIMBIC DOPAMINE, NUCLEUS-ACCUMBENS, CHOICE BEHAVIOR, MOTIVATIONAL SYMPTOMS, ADENOSINE A(2A), ACUTE STRESS, COCAINE, MODAFINIL, Synthesis, Motivation, Dopamine, Depression, Fatigue, Anergia, Modafinil, Transport",

author = "Rotolo, \{Renee A.\} and Vladimir Dragacevic and Predrag Kalaba and Ernst Urban and Martin Zehl and Alexander Roller and Judith Wackerlig and Thierry Langer and Marco Pistis and \{De Luca\}, \{Maria Antonietta\} and Francesca Caria and Rebecca Schwartz and Presby, \{Rose E.\} and Jen-Hau Yang and Shanna Samels and Merce Correa and Gert Lubec and Salamone, \{John D.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Rotolo, Dragacevic, Kalaba, Urban, Zehl, Roller, Wackerlig, Langer, Pistis, De Luca, Caria, Schwartz, Presby, Yang, Samels, Correa, Lubec and Salamone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.",

year = "2019",

month = jun,

day = "28",

doi = "10.3389/fphar.2019.00682",

language = "English",

volume = "10",

journal = "Frontiers in Pharmacology",

issn = "1663-9812",

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Rotolo, RA, Dragacevic, V, Kalaba, P, Urban, E, Zehl, M, Roller, A, Wackerlig, J , Langer, T, Pistis, M, De Luca, MA, Caria, F, Schwartz, R, Presby, RE, Yang, J-H, Samels, S, Correa, M, Lubec, G & Salamone, JD 2019, 'The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding', Frontiers in Pharmacology, vol. 10, 682. https://doi.org/10.3389/fphar.2019.00682

The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. / Rotolo, Renee A.; Dragacevic, Vladimir; Kalaba, Predrag et al.
In: Frontiers in Pharmacology, Vol. 10, 682, 28.06.2019.

Publications: Contribution to journal › Article › Peer Reviewed

TY - JOUR

T1 - The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding

AU - Rotolo, Renee A.

AU - Dragacevic, Vladimir

AU - Kalaba, Predrag

AU - Urban, Ernst

AU - Zehl, Martin

AU - Roller, Alexander

AU - Wackerlig, Judith

AU - Langer, Thierry

AU - Pistis, Marco

AU - De Luca, Maria Antonietta

AU - Caria, Francesca

AU - Schwartz, Rebecca

AU - Presby, Rose E.

AU - Yang, Jen-Hau

AU - Samels, Shanna

AU - Correa, Merce

AU - Lubec, Gert

AU - Salamone, John D.

N1 - Publisher Copyright: © 2019 Rotolo, Dragacevic, Kalaba, Urban, Zehl, Roller, Wackerlig, Langer, Pistis, De Luca, Caria, Schwartz, Presby, Yang, Samels, Correa, Lubec and Salamone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PY - 2019/6/28

Y1 - 2019/6/28

KW - dopamine

KW - transport

KW - synthesis

KW - motivation

KW - depression

KW - fatigue

KW - anergia

KW - modafinil

KW - MAJOR DEPRESSIVE DISORDER

KW - DECISION-MAKING

KW - MESOLIMBIC DOPAMINE

KW - NUCLEUS-ACCUMBENS

KW - CHOICE BEHAVIOR

KW - MOTIVATIONAL SYMPTOMS

KW - ADENOSINE A(2A)

KW - ACUTE STRESS

KW - COCAINE

KW - MODAFINIL

KW - Synthesis

KW - Motivation

KW - Dopamine

KW - Depression

KW - Fatigue

KW - Anergia

KW - Modafinil

KW - Transport

UR - https://www.scopus.com/pages/publications/85069526792

U2 - 10.3389/fphar.2019.00682

DO - 10.3389/fphar.2019.00682

M3 - Article

SN - 1663-9812

VL - 10

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 682

ER -

The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding

Funding

Austrian Fields of Science 2012

Keywords

Access to Document

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