The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol

Peter Kotora; Frantisek Sersen; Juraj Filo; Dusan Loos; Juraj Gregan; Fridrich Gregan

doi:10.3390/molecules21010127

The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol

Peter Kotora, Frantisek Sersen, Juraj Filo, Dusan Loos, Juraj Gregan, Fridrich Gregan

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

Resveratrol (3,5,41-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,21-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.

Original language	English
Article number	127
Number of pages	13
Journal	Molecules
Volume	21
Issue number	1
DOIs	https://doi.org/10.3390/molecules21010127
Publication status	Published - Jan 2016

Austrian Fields of Science 2012

106023 Molecular biology

Keywords

resveratrol analogs
iminophenols
antioxidant activity
ANTIOXIDANT ACTIVITIES
DISEASE
WINE
DERIVATIVES
MOLECULE
DESIGN
ACIDS
Antioxidant activity
Resveratrol analogs
Iminophenols

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules21010127Licence: CC BY 4.0

http://phaidra.univie.ac.at/o:533939Licence: CC BY 4.0

Cite this

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title = "The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol",

abstract = "Resveratrol (3,5,41-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,21-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.",

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author = "Peter Kotora and Frantisek Sersen and Juraj Filo and Dusan Loos and Juraj Gregan and Fridrich Gregan",

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doi = "10.3390/molecules21010127",

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T1 - The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol

AU - Kotora, Peter

AU - Sersen, Frantisek

AU - Filo, Juraj

AU - Loos, Dusan

AU - Gregan, Juraj

AU - Gregan, Fridrich

PY - 2016/1

Y1 - 2016/1

N2 - Resveratrol (3,5,41-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,21-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.

AB - Resveratrol (3,5,41-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,21-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs.

KW - resveratrol analogs

KW - iminophenols

KW - antioxidant activity

KW - ANTIOXIDANT ACTIVITIES

KW - DISEASE

KW - WINE

KW - DERIVATIVES

KW - MOLECULE

KW - DESIGN

KW - ACIDS

KW - Antioxidant activity

KW - Resveratrol analogs

KW - Iminophenols

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U2 - 10.3390/molecules21010127

DO - 10.3390/molecules21010127

M3 - Article

SN - 1420-3049

VL - 21

JO - Molecules

JF - Molecules

IS - 1

M1 - 127

ER -

The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol

Abstract

Austrian Fields of Science 2012

Keywords

UN SDGs

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