TY - JOUR
T1 - Thr94 and Wat2b effect protonation of the retinal chromophore in rhodopsin
AU - Buss, Volker
AU - Sugihara, Minoru
AU - Entel, Peter
AU - Hafner, Juergen
N1 - Zeitschrift: Angewandte Chemie - International Edition
Coden: ACIEA
Affiliations: Institut für Chemie, Universität Duisburg-Essen, 47048 Duisburg, Germany; Inst. Theor. Tieftemperaturphysik, Universität Duisburg-Essen, 47048 Duisburg, Germany; Institut für Materialphysik, Universität Wien, 1090 Wien, Austria
Adressen: Buss, V.; Institut für Chemie; Universität Duisburg-Essen 47048 Duisburg, Germany; email: [email protected]
Import aus Scopus: 2-s2.0-0042768527
22.10.2007: Datenanforderung 1935 (Import Sachbearbeiter)
22.10.2007: Datenanforderung 1936 (Import Sachbearbeiter)
PY - 2003
Y1 - 2003
N2 - Only with the help from (little) "friends" is it possible for the 11-cis-retinal Schiff base to compete successfully against Glu 113 for a proton (see pisture). A strategically placed amino acid, Thr94, plus a water molecule are sufficient to reduce the basicity of the glutamate and stabilize the protonated chromophore - this is the result of ab initio optimization and molecular-dynamic study of the retinal binding site in rhodopsin.
AB - Only with the help from (little) "friends" is it possible for the 11-cis-retinal Schiff base to compete successfully against Glu 113 for a proton (see pisture). A strategically placed amino acid, Thr94, plus a water molecule are sufficient to reduce the basicity of the glutamate and stabilize the protonated chromophore - this is the result of ab initio optimization and molecular-dynamic study of the retinal binding site in rhodopsin.
U2 - 10.1002/anie.200351034
DO - 10.1002/anie.200351034
M3 - Article
SN - 1433-7851
VL - 42
SP - 3245
EP - 3247
JO - Angewandte Chemie (International Edition)
JF - Angewandte Chemie (International Edition)
IS - 28
ER -