TY - JOUR
T1 - Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy
AU - Wang, Youchao
AU - Felder, Patrick S.
AU - Mesdom, Pierre
AU - Blacque, Olivier
AU - Mindt, Thomas L.
AU - Cariou, Kevin
AU - Gasser, Gilles
N1 - Accession Number: WOS:001045818600001
PubMed ID: 37526951
Publisher Copyright:
© 2023 The Authors. ChemBioChem published by Wiley-VCH GmbH.
PY - 2023/10/4
Y1 - 2023/10/4
N2 - The search for new metal-based photosensitizers (PSs) for anticancer photodynamic therapy (PDT) is a fast-developing field of research. Knowing that polymetallic complexes bear a high potential as PDT PSs, in this study, we aimed at combining the known photophysical properties of a rhenium(I) tricarbonyl complex and a ruthenium(II) polypyridyl complex to prepare a ruthenium-rhenium binuclear complex that could act as a PS for anticancer PDT. Herein, we present the synthesis and characterization of such a system and discuss its stability in aqueous solution. In addition, one of our complexes prepared, which localized in mitochondria, was found to have some degree of selectivity towards two types of cancerous cells: human lung carcinoma A549 and human colon colorectal adenocarcinoma HT29, with interesting photo-index (PI) values of 135.1 and 256.4, respectively, compared to noncancerous retinal pigment epithelium RPE1 cells (22.4).
AB - The search for new metal-based photosensitizers (PSs) for anticancer photodynamic therapy (PDT) is a fast-developing field of research. Knowing that polymetallic complexes bear a high potential as PDT PSs, in this study, we aimed at combining the known photophysical properties of a rhenium(I) tricarbonyl complex and a ruthenium(II) polypyridyl complex to prepare a ruthenium-rhenium binuclear complex that could act as a PS for anticancer PDT. Herein, we present the synthesis and characterization of such a system and discuss its stability in aqueous solution. In addition, one of our complexes prepared, which localized in mitochondria, was found to have some degree of selectivity towards two types of cancerous cells: human lung carcinoma A549 and human colon colorectal adenocarcinoma HT29, with interesting photo-index (PI) values of 135.1 and 256.4, respectively, compared to noncancerous retinal pigment epithelium RPE1 cells (22.4).
KW - bioinorganic chemistry
KW - metals in medicine
KW - photodynamic therapy
KW - Rhenium(I) complex
KW - Ruthenium(II) complex
UR - http://www.scopus.com/inward/record.url?scp=85167650918&partnerID=8YFLogxK
U2 - 10.1002/cbic.202300467
DO - 10.1002/cbic.202300467
M3 - Article
C2 - 37526951
AN - SCOPUS:85167650918
SN - 1439-4227
VL - 24
JO - ChemBioChem
JF - ChemBioChem
IS - 19
M1 - e202300467
ER -
