Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation

Sonja M Kessler, Stephan Laggai, Elien Van Wonterg, Katja Gemperlein, Rolf Müller, Johannes Haybaeck, Roosmarijn E Vandenbroucke, Manfred Ogris, Claude Libert, Alexandra K Kiemer

    Publications: Contribution to journalArticlePeer Reviewed

    Original languageEnglish
    Article number147
    Number of pages11
    JournalFrontiers in Physiology
    Volume7
    DOIs
    Publication statusPublished - 25 Apr 2016

    Austrian Fields of Science 2012

    • 301207 Pharmaceutical chemistry

    Keywords

    • Journal Article
    • PPAR-ALPHA
    • FATTY LIVER-DISEASE
    • IGF2
    • NONALCOHOLIC STEATOHEPATITIS
    • fatty liver
    • NASH
    • lipid droplets
    • insulin-like growth factor 2 (IGF2)
    • HEPATOCELLULAR-CARCINOMA
    • BINDING-PROTEIN P62/IGF2BP2-2
    • STEATOSIS
    • GENE-EXPRESSION
    • VIRUS CORE PROTEIN
    • OBESE
    • hydrodynamic gene delivery
    • Lipid droplets
    • Hydrodynamic gene delivery
    • Fatty liver
    • Insulin-like growth factor 2 (IGF2)

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