Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation

Claudia Karnthaler-Benbakka; Diana Groza; Kushtrim Kryeziu; Verena Pichler; Alexander Roller; Walter Berger; Petra Heffeter; Christian R. Kowol

doi:10.1002/anie.201403936

Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation

Claudia Karnthaler-Benbakka
, Diana Groza
, Kushtrim Kryeziu
, Verena Pichler
, Alexander Roller
, Walter Berger
, Petra Heffeter (Corresponding author)
, Christian R. Kowol

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	12930-12935
Number of pages	6
Journal	Angewandte Chemie (International Edition)
Volume	53
Issue number	47
DOIs	https://doi.org/10.1002/anie.201403936
Publication status	Published - 17 Nov 2014

Funding

This work was supported by the Fonds der Stadt Wien fur innovative interdisziplinaere Krebsforschung, the FWF (P26603), and the COST action CM1105. We thank Prof. Mag. Dr. Walter Weissensteiner, University of Vienna, for helpful discussions. The authors declare a conflict of interest, as the lead compound is covered by a patent application.

Austrian Fields of Science 2012

104003 Inorganic chemistry
301904 Cancer research

Keywords

anticancer drugs
cobalt
hypoxia
prodrugs
tyrosine-kinase inhibitors
RECEPTOR TYROSINE KINASE
METAL-COMPLEXES
CANCER
PRODRUG
DERIVATIVES
THERAPY
AGENTS
Prodrugs
Anticancer drugs
Tyrosine-kinase inhibitors
Cobalt
Hypoxia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201403936

Cite this

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title = "Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation",

keywords = "anticancer drugs, cobalt, hypoxia, prodrugs, tyrosine-kinase inhibitors, RECEPTOR TYROSINE KINASE, METAL-COMPLEXES, CANCER, PRODRUG, DERIVATIVES, THERAPY, AGENTS, Prodrugs, Anticancer drugs, Tyrosine-kinase inhibitors, Cobalt, Hypoxia",

author = "Claudia Karnthaler-Benbakka and Diana Groza and Kushtrim Kryeziu and Verena Pichler and Alexander Roller and Walter Berger and Petra Heffeter and Kowol, \{Christian R.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2014",

month = nov,

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doi = "10.1002/anie.201403936",

language = "English",

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T1 - Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation

AU - Karnthaler-Benbakka, Claudia

AU - Groza, Diana

AU - Kryeziu, Kushtrim

AU - Pichler, Verena

AU - Roller, Alexander

AU - Berger, Walter

AU - Heffeter, Petra

AU - Kowol, Christian R.

PY - 2014/11/17

Y1 - 2014/11/17

KW - anticancer drugs

KW - cobalt

KW - hypoxia

KW - prodrugs

KW - tyrosine-kinase inhibitors

KW - RECEPTOR TYROSINE KINASE

KW - METAL-COMPLEXES

KW - CANCER

KW - PRODRUG

KW - DERIVATIVES

KW - THERAPY

KW - AGENTS

KW - Prodrugs

KW - Anticancer drugs

KW - Tyrosine-kinase inhibitors

KW - Cobalt

KW - Hypoxia

UR - https://www.scopus.com/pages/publications/84941065402

U2 - 10.1002/anie.201403936

DO - 10.1002/anie.201403936

M3 - Article

SN - 1433-7851

VL - 53

SP - 12930

EP - 12935

JO - Angewandte Chemie (International Edition)

JF - Angewandte Chemie (International Edition)

IS - 47

ER -

Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation

Funding

Austrian Fields of Science 2012

Keywords

UN SDGs

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