Type I Interferons in Immune Defense Against Streptococci

Pavel Kovarik; Virginia Castiglia; Janos Marton

doi:10.1007/978-3-319-09498-4_4

Type I Interferons in Immune Defense Against Streptococci

Pavel Kovarik (Corresponding author), Virginia Castiglia, Janos Marton

Department of Microbiology, Immunobiology and Genetics

Publications: Contribution to book › Chapter

Abstract

Infections with Streptococcus pneumoniae, Group A Streptococcus (GAS), and Group B Streptococcus (GBS) are among the most frequent bacterial infections in humans and major causes of diseases. Immune responses against streptococci include the induction of type I interferons (IFNs), which are immunomodulatory cytokines with well-established antiviral functions, but ambiguous roles in bacterial infections. Studies of streptococcal infections further highlight the importance of type I IFN signaling in host defense against bacterial pathogens. We discuss the complexity of type I IFN induction by streptococcal ligands and their engagement in stimulating innate immune receptors. Furthermore, we elaborate on the broad physiological role and different impacts of type I IFN signaling on the outcome of streptococcal infections and influenza virus coinfections.

Original language	English
Title of host publication	Bacterial Activation of Type I Interferons
Editors	Dane Parker
Place of Publication	Cham
Publisher	Springer
Pages	43-59
Number of pages	17
ISBN (Electronic)	978-3-319-09498-4
ISBN (Print)	3319094971, 9783319094977
DOIs	https://doi.org/10.1007/978-3-319-09498-4_4
Publication status	Published - 2014

Austrian Fields of Science 2012

301902 Immunology
106022 Microbiology
303020 Medical microbiology

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title = "Type I Interferons in Immune Defense Against Streptococci",

abstract = "Infections with Streptococcus pneumoniae, Group A Streptococcus (GAS), and Group B Streptococcus (GBS) are among the most frequent bacterial infections in humans and major causes of diseases. Immune responses against streptococci include the induction of type I interferons (IFNs), which are immunomodulatory cytokines with well-established antiviral functions, but ambiguous roles in bacterial infections. Studies of streptococcal infections further highlight the importance of type I IFN signaling in host defense against bacterial pathogens. We discuss the complexity of type I IFN induction by streptococcal ligands and their engagement in stimulating innate immune receptors. Furthermore, we elaborate on the broad physiological role and different impacts of type I IFN signaling on the outcome of streptococcal infections and influenza virus coinfections.",

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AU - Marton, Janos

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N2 - Infections with Streptococcus pneumoniae, Group A Streptococcus (GAS), and Group B Streptococcus (GBS) are among the most frequent bacterial infections in humans and major causes of diseases. Immune responses against streptococci include the induction of type I interferons (IFNs), which are immunomodulatory cytokines with well-established antiviral functions, but ambiguous roles in bacterial infections. Studies of streptococcal infections further highlight the importance of type I IFN signaling in host defense against bacterial pathogens. We discuss the complexity of type I IFN induction by streptococcal ligands and their engagement in stimulating innate immune receptors. Furthermore, we elaborate on the broad physiological role and different impacts of type I IFN signaling on the outcome of streptococcal infections and influenza virus coinfections.

AB - Infections with Streptococcus pneumoniae, Group A Streptococcus (GAS), and Group B Streptococcus (GBS) are among the most frequent bacterial infections in humans and major causes of diseases. Immune responses against streptococci include the induction of type I interferons (IFNs), which are immunomodulatory cytokines with well-established antiviral functions, but ambiguous roles in bacterial infections. Studies of streptococcal infections further highlight the importance of type I IFN signaling in host defense against bacterial pathogens. We discuss the complexity of type I IFN induction by streptococcal ligands and their engagement in stimulating innate immune receptors. Furthermore, we elaborate on the broad physiological role and different impacts of type I IFN signaling on the outcome of streptococcal infections and influenza virus coinfections.

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BT - Bacterial Activation of Type I Interferons

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Type I Interferons in Immune Defense Against Streptococci

Abstract

Austrian Fields of Science 2012

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